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1.) Ca(2+)/calmodulin regulates salicylic-acid-mediated plant immunity.
2.) Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
3.) Gravitational astronomy 101.
4.) Chaperonin complex with a newly folded protein encapsulated in the folding chamber.
5.) Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.
6.) Indirect reciprocity provides only a narrow margin of efficiency for costly punishment.
7.) Seismic evidence for overpressured subducted oceanic crust and megathrust fault sealing.
8.) Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides.
9.) Squeezing and over-squeezing of triphotons.
10.) A role for self-gravity at multiple length scales in the process of star formation.
11.) Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
12.) 18 years of science with the Hubble Space Telescope.
13.) Darwin 200: A natural selection.
14.) Game theory: How to treat those of ill repute.
15.) Astrophysics: Star formation branches out.
16.) 50 & 100 years ago.
17.) Cancer: Inflaming metastasis.
18.) Quantum physics: Squeeze until it hurts.
19.) Year of astronomy: Hidden treasures: the Paris Observatory.
20.) Year of astronomy: Star poetry.
21.) Year of astronomy: Q&A: One giant leap for art. Interview by Daniel Cressey.
22.) Year of astronomy: Voyaging to discovery, alone.
23.) Year of astronomy: Visions of ourselves.
24.) Year of astronomy: Mankind's place in the Universe.
25.) Time to turn off the lights.
26.) Problems with anti-plagiarism database.
27.) Obama must match science rhetoric with action.
28.) Honeybee and the Phoenix analysing instrument.
29.) Year of astronomy: New eyes, new skies.
30.) The new boss in town.
31.) Medical charity folds after investment losses.
32.) US firms power up to build advanced batteries.
33.) Health organization lays plans for major biobank.
34.) Spanish solar companies slammed over subsidy fraud.
35.) Correction.
36.) NASA awards contracts to supply space station.
37.) First antenna switches on in the Atacama.
38.) Single fund for African science aid.
39.) Good grades, but who gets the cash?
40.) Universities struggle as value of endowments falls.
41.) Obama's picks underline climate focus.
42.) A public service.
43.) Announcement: Evolutionary gems.
44.) Starry messages.
45.) Experts still needed.
46.) Making the paper: Dan Barouch.
47.) Abstractions.
48.) From the Blogosphere.
49.) Calcium flickers steer cell migration.
50.) The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
51.) Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
52.) Photon capture and signalling by melanopsin retinal ganglion cells.
53.) Pyrrolysyl-tRNA synthetase-tRNA(Pyl) structure reveals the molecular basis of orthogonality.
54.) Direct observation of the nanoscale dynamics of membrane lipids in a living cell.
55.) Artificial nanopores that mimic the transport selectivity of the nuclear pore complex.
56.) Nodal signalling is involved in left-right asymmetry in snails.
57.) Induced pluripotent stem cells from a spinal muscular atrophy patient.
58.) A stress-responsive RNA switch regulates VEGFA expression.
59.) Harnessing the brane-deer.
60.) Conformational changes in an ultrafast light-driven enzyme determine catalytic activity.
61.) How supercontinents and superoceans affect seafloor roughness.
62.) Unconventional superconductivity in Ba(0.6)K(0.4)Fe2As2 from inelastic neutron scattering.
63.) A gravitationally lensed water maser in the early Universe.
64.) Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.
65.) SUMOylation regulates Rad18-mediated template switch.
66.) Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation.
67.) Geometric frustration in buckled colloidal monolayers.
68.) Sensing voltage across lipid membranes.
69.) Ralph lewin (1921-2008).
70.) Biogeochemistry: nitrous oxide in flux.
71.) Neuroscience: greasy proteins of the neuron.
72.) Condensed-matter physics: the eternal triangle.
73.) Epigenetics: how to lose a tail.
74.) Organometallic chemistry: catalyst takes control to heart.
75.) Circadian clocks: tips from the tip of the iceberg.
76.) Quantum physics: don't look now.
77.) Molecular biology: spliceosome meets telomerase.
78.) Migration: an engine for social change.
79.) Looking at the face of the Earth.
80.) The science communicator.
81.) Does genius breed success?
82.) A wonderful life by leaps and bounds.
83.) Three rules for technological fixes.
84.) Correction.
85.) You're the best man for this job, son. What a coincidence!
86.) Online archives are revealing uncensored history of science.
87.) Finding of unusual soil on Mars could stem from tools used.
88.) US nanotechnology plan lacks risk research.
89.) Rift-valley countries set for geothermal power.
90.) Lectures gain electronic life in Egyptian library.
91.) Vatican formalizes rules on human stem-cell research.
92.) US bioindustry calls for government bailout.
93.) Michigan State wins battle to host isotope accelerator.
94.) Salary for CIRM head despite deficit.
95.) News 2008.
96.) Medicine: A breath of fresh air.
97.) Immunology: Successful delivery.
98.) Photonics: Telescopic TV.
99.) Neurobiology: The motor-neuron driver.
100.) Geoscience: The speed of ice.
101.) The year in Nature.
102.) Physics: Black holes on the strand.
103.) Cell biology: Bent out of shape.
104.) Evolution: Yeast rewired.
105.) Geology: Magma mix-up.
106.) Molecular biology: Shaping up.
107.) Astrophysics: Cosmic tiara.
108.) Genetics: Many but rare.
109.) Evolution: Genetic bric-a-brac.
110.) Biochemistry: Catalytic creator.
111.) Organic chemistry: Tag-team catalysts.
112.) Neuroscience: MRI beebop.
113.) Human biology: Bird's eye view.
114.) Biophysics: Mob rule.
115.) Economics: A healthier haul.
116.) Neuroscience: Glia on fire.
117.) Zoology: queen bee.
118.) Nanotechnology: Super speakers.
119.) Eyes west.
120.) Machine-makers matter.
121.) Facilitating the future.
122.) Making the paper: Manolo Gouy.
123.) From the blogosphere.
124.) Abstractions.
125.) Peltier & Liu reply.
126.) Carbon cycling and snowball Earth.
127.) Snowball prevention questioned.
128.) Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
129.) Quality control by the ribosome following peptide bond formation.
130.) Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.
131.) Crypt stem cells as the cells-of-origin of intestinal cancer.
132.) The DNA-encoded nucleosome organization of a eukaryotic genome.
133.) WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
134.) RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light.
135.) Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.
136.) Sleep and sensorimotor integration during early vocal learning in a songbird.
137.) Messenger RNA targeting to endoplasmic reticulum stress signalling sites.
138.) The unfolded protein response signals through high-order assembly of Ire1.
139.) Cell imaging: Light activated.
140.) Cell imaging: New ways to see a smaller world.
141.) Retraction. The RNA-binding protein FCA is an abscisic acid receptor.
142.) Strain accommodation by slow slip and dyking in a youthful continental rift, East Africa.
143.) Enantiodivergent conversion of chiral secondary alcohols into tertiary alcohols.
144.) A solid-state light-matter interface at the single-photon level.
145.) Strong ocean tidal flow and heating on moons of the outer planets.
146.) Strong water absorption in the dayside emission spectrum of the planet HD 189733b.
147.) Negative feedback that improves information transmission in yeast signalling.
148.) Antigenic variation in Giardia lamblia is regulated by RNA interference.
149.) Reverse engineering the genotype-phenotype map with natural genetic variation.
150.) A global network for investigating the genomic epidemiology of malaria.
151.) Progress and challenges in genome-wide association studies in humans.
152.) Applying mouse complex-trait resources to behavioural genetics.
153.) Next-generation genetics in plants.
154.) Quantitative genetics.
155.) Obituary: martin lindauer (1918-2008).
156.) Materials science: Deformation of the ultra-strong.
157.) Neuroscience: Brain power.
158.) Astrophysics: Quest for a habitable world.
159.) Microbial ecology: Metabolism of the deep.
160.) Organic chemistry: How to beat an alcohol problem.
161.) Q&A: Helium walks into a bar... Interview by Nick Thomas.
162.) The food crisis isn't over.
163.) Bovine TB: stopping disease control would block all live exports.
164.) Bovine TB: don't get rid of the cat because the mice have gone.
165.) Right environment can enhance 'innate' entrepreneurial skills.
166.) Cell biology: Stretching the imagination.
167.) Mars exploration: Phoenix: a race against time.
168.) Kansas wins race to host biodefence research centre.
169.) UN suspends leading carbon-offset firm.
170.) Patent pledge to Indian universities.
171.) India creates funding council for basic science.
172.) Plant hormone study pulled.
173.) Feathers fly over Hawaiian bird.
174.) Rule change for human grants sparks spat at NIH.
175.) France cracks down on Iranian scientists.
176.) Malaria vaccine gets shot in the arm from tests.
177.) Journal club: a neuroscientist marvels at our ability to learn unnatural tasks.
178.) Failure in the field.
179.) Watching big brother.
180.) What next for Mars?
181.) FCA does not bind abscisic acid.
182.) Contact inhibition of locomotion in vivo controls neural crest directional migration.
183.) Endochondral ossification is required for haematopoietic stem-cell niche formation.
184.) Detoxification of sulphidic African shelf waters by blooming chemolithotrophs.
185.) Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.
186.) Enhancing SIV-specific immunity in vivo by PD-1 blockade.
187.) Endonucleolytic RNA cleavage by a eukaryotic exosome.
188.) Towards responsible use of cognitive-enhancing drugs by the healthy.
189.) Detection of functional haematopoietic stem cell niche using real-time imaging.
190.) Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.
191.) Spliceosomal cleavage generates the 3' end of telomerase RNA.
192.) MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.
193.) Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.
194.) Parallel adaptations to high temperatures in the Archaean eon.
195.) Major gradients in putatively nitrifying and non-nitrifying Archaea in the deep North Atlantic.
196.) Successful range-expanding plants experience less above-ground and below-ground enemy impact.
197.) The replisome uses mRNA as a primer after colliding with RNA polymerase.
198.) Emergence of complex cell properties by learning to generalize in natural scenes.
199.) Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
200.) Structural recognition and functional activation of FcgammaR by innate pentraxins.
201.) Low conservation of gene content in the Drosophila Y chromosome.
202.) Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis.
203.) Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis.
204.) A role for VEGF as a negative regulator of pericyte function and vessel maturation.
205.) Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys.
206.) X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
207.) X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.
208.) Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.
209.) G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
210.) Temporal identity in axonal target layer recognition.
211.) Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons.
212.) Brain metabolism dictates the polarity of astrocyte control over arterioles.
213.) Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions.
214.) Experience with moving visual stimuli drives the early development of cortical direction selectivity.
215.) Generation of a prostate from a single adult stem cell.
216.) Strong effect of dispersal network structure on ecological dynamics.
217.) DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes.